書誌事項
- タイトル別名
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- Suppressive Effect of Herbal Medicine Dokkatsu-kisei-to on Mouse Type II Collagen-induced Arthritis.
- マウスコラーゲン カンセツエン ニ タイスル ドッカツキセイ トウ ノ エイキョウ
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抄録
Collagen-induced arthritis (CIA) in DBA/1J mice is an autoimmune model driven by the combination of humoral and cellular immunity against cartilage type II collagen. It has been proven to be a useful model for human rheumatoid arthritis (RA). This study was designed to obtain experimental evidence of Kampo medicine Dokkatsu-kisei-to (DKT) in the treatment of RA by using mouse CIA. As positive control, prednisolone was given. The significant suppressive effect of DKT as measured by arthritis score persisted upon cessation of treatment on day 42 and remained until the termination of the experiment on day 63. The amelioration of inflammatory articular lesions was confirmed by radiological and histo-pathological findings. We also observed significantly decreased concentrations of serum TNF-α on day 28 and levels of serum IgG antibody against bovine type II collagen on day 49. These results suggest that DKT has important effects on immuno-inflammatory response and may be useful in the prevention of the onset and severity of arthritis.
収録刊行物
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- 日本東洋医学雑誌
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日本東洋医学雑誌 54 (4), 763-771, 2003
一般社団法人 日本東洋医学会
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詳細情報 詳細情報について
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- CRID
- 1390282679883938688
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- NII論文ID
- 10016195635
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- NII書誌ID
- AN00015774
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- ISSN
- 1882756X
- 02874857
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- NDL書誌ID
- 6657225
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可