Clinical evaluation of a novel membrane plasma separator for donor plasmapheresis.
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- Osada Koji
- Department of Transfusion Medicine, Tokyo Women's Medical College
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- Fujii Hisaichi
- Department of Transfusion Medicine, Tokyo Women's Medical College
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- Shimizu Masaru
- Department of Transfusion Medicine, Tokyo Women's Medical College
Bibliographic Information
- Other Title
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- 採血バックの加圧減圧式採血装置と連結した膜型血しょう分離システム(テルモMS‐201)の臨床評価
Abstract
For the purpose of making Donor Plasmapheresis (DP) more popular, a novel device (MS-201, TERUMO Corporation, Tokyo) for DP has been developed, which is composed of a membrane plasma separator, a blood and a plasma collection bag each and connected tubes. The module consists of 16 circular layers of the membrane made of polypropylene coated with hydrophilic polymers. This device requires no priming operation with saline. DP using this system was carried out on 31 healthy male donors.<br>This device functioned well to collect plasma and was accepted favorably by the donors. None of the donors experienced adverse effects. Our study showed that the module had good biocompatibility since mean values of activation markers of complement (C3a and C5a), platelet (β-TG, PF-4) and coagulation (FPA) as well as hemolysis (free Hb, Hp, LDH) increased a little more than or within normal limits. The recovery and sieving coefficients of TP, Alb, AT-III, F-VIII and Fibrinogen were more than 0.95.<br>It took a mean time of 33.7±6.2 minutes from needle punctures of vein to collecting 450ml of plasma including anticoagulant.<br>In conclusion, this donor plasmapheresis system could be safely used and easily accepted to process in mobiles with a portable size.
Journal
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- Journal of the Japan Society of Blood Transfusion
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Journal of the Japan Society of Blood Transfusion 39 (6), 959-966, 1993
The Japan Society of Transfusion Medicine and Cell Therapy
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Details 詳細情報について
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- CRID
- 1390282679883945728
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- NII Article ID
- 130003852890
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- ISSN
- 18838383
- 05461448
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed