Glucocorticoid-like and Glucocorticoid-unlike Regulation of Gene Expression by Bakumondo-to(Mai-Men-Dong-Tang) in Airway Epithelial Cells.
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- ISOHAMA Yoichiro
- Department of Phamacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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- MORIUCHI Hiroshi
- Department of Phamacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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- KAI Hirofumi
- Department of Phamacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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- MIYATA Takeshi
- Department of Phamacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
Bibliographic Information
- Other Title
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- 肺上皮細胞における麦門冬湯のグルココルチコイド依存性および非依存性遺伝子発現調節作用
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Abstract
Since many patients are still dying from asthma and COPD, developing more effective drugs with little side-effect which can be taken for a long time, is very important. Clinical usage of herbal medicines for chronic airway diseases has been increasing. Bakumondo-to is a useful herbal medicine with little side-effect for the treatment of chronic airway diseases. There are some similarities of pharmacological profile of herbal medicines to those of glucocorticoids. Although the regulation of gene expression by glucocorticoids has been clarified, that of Bakumondo-to is not well known. Elucidation of the mechanism of Bakumondo-to will be helpful in establishing a more effective treatment of chronic airway diseases. This article focuses on the regulation of gene expression by Bakumondo-to in airway epithelial cells, and describes the increase in mRNA expression for β-adrenergic receptors by Bakumondo-to and in glucocorticoid-sensitive promoter activity. We also discuss the mechanisms of the regulatory action of Bakumondo-to.
Journal
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- Kampo Medicine
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Kampo Medicine 53 (1/2), 1-9, 2002
The Japan Society for Oriental Medicine
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Keywords
Details 詳細情報について
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- CRID
- 1390282679883996928
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- NII Article ID
- 110004002071
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- NII Book ID
- AN00015774
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- ISSN
- 1882756X
- 02874857
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- NDL BIB ID
- 6135819
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed