ＣＰＤ液で採血した血液の全血処理型白血球除去ＷＢＦフイルタークローズドシステムの性能評価
書誌事項
- タイトル別名
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- EVALUATION OF QUALITIES ON A CLOSED SYSTEM USING THE WHOLE BLOOD LEUKOCYTE DEPLETION FILTER (WBF) FOR PRE-STORAGE
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説明
To prevent the post-transfusion reactions in transfusion therapy such as HLA alloimmunization, non-hemolytic febrile transfusion reaction (NHFTR) and Cytomegalovirus transmission, bedside leukocyte reduction has been performed. However, it has become clear that prestorage leukocyte reduction has greater efficiency than poststorage, and prestorage leukocyte reduction is now being considered for implementation. We developed a prestorage leukocyte reduction system that contains CPD anticoagulant solution (PLD-C system). In this study, the performance of the PLD-C system was examined with regard to the leukocyte filtration efficacy and the characteristics of blood during storage by comparison with a pre-storage leukocyte reduction system which uses ACD-A solution (PLD-A system) and blood components collected using CPD solution and prepared by the buffy-coat depleted method (BCPD).<br>It was confirmed that the leukocyte reduction ratio of the PLD-C system (more than-4log) was higher than that of the BCPD (less than-0.4log). Platelet depletion rates of the PLD-C group (average more than 99%) was also higher than in the BCPD group, but the red cell recovery ratio was the same between groups (average 88%). Prestorage filtration showed no adverse effects such as hemolysis, whereas various good effects were observed, such as inhibition of macroaggregate formation and hemolysis during storage. Collecting blood into CPD solution improved red cell quality during storage and increased plasma volume compared to the ACD-A solution.<br>It was confirmed that the PLD-C system has advantages in the production of blood components over the present system. Use of this system can be expected to prevent post transfusion reactions.
収録刊行物
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- 日本輸血学会雑誌
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日本輸血学会雑誌 50 (1), 56-67, 2004
一般社団法人 日本輸血・細胞治療学会
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詳細情報 詳細情報について
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- CRID
- 1390282679884481536
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- NII論文ID
- 130003853213
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- ISSN
- 18838383
- 05461448
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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