The Dose of Sulfonylurea Agents Should Be Halved When a DPP-4 Inhibitor Is Added, Regardless of the Previous Dose of the Sulfonylurea Agent
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- Kurihara Yoshio
- Medical Corporation Touyuukai Kurihara Clinic
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- Yamashita Kumiko
- Medical Corporation Touyuukai Kurihara Clinic
Bibliographic Information
- Other Title
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- DPP-4阻害薬追加時のスルホニル尿素薬はその量に関係なく一旦半減するのが適切な調節であると考える
- DPP-4 ソガイヤク ツイカジ ノ スルホニル ニョウソヤク ワ ソノ リョウ ニ カンケイ ナク イッタン ハンゲン スル ノ ガ テキセツ ナ チョウセツ デ アル ト カンガエル
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Abstract
We retrospectively investigated the dose regulation of sulfonylurea (SU) agents in 219 patients who received dipeptidyl peptidase-4 (DPP-4) inhibitors in addition to SU-based treatment. Of 169 patients who received sitagliptin in addition to SU-based treatment without reducing the dose of the SU agent, 46 (27 %) patients required a reduction of the SU agent within three months for hypoglycemia or to prevent hypoglycemia. Moreover, hypoglycemia occurred in nine (20 %) patients who had been treated with an SU agent at a dose lower than the recommended dose when a DPP-4 inhibitor was added without reducing the dose of the SU agent. However, in 50 patients, when the SU agent was reduced to approximately half the dose, no hypoglycemia was observed, regardless of the previous dose, although the HbA1c-lowering effect was not significantly different from that observed in the patients treated without dose reduction (-0.9 %vs-0.9 %, p=0.95). Therefore, we consider that the dose of SU agents should be halved when a DPP-4 inhibitor is added, regardless of the previous dose of the SU agent.
Journal
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- Journal of the Japan Diabetes Society
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Journal of the Japan Diabetes Society 56 (11), 892-896, 2013
THE JAPAN DIABETES SOCIETY
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Details 詳細情報について
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- CRID
- 1390282679884902912
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- NII Article ID
- 130004905377
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- NII Book ID
- AN00166576
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- ISSN
- 1881588X
- 0021437X
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- NDL BIB ID
- 025062502
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed