Studies on the Effects of Rikkunshi-to and Hochu-ekki-to on Adrenal and Autonomic Nervous Functions.

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  • OKA Takakazu
    Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University
  • KOMIYAMA Hiroaki
    Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University
  • NAKAGAWA Tetsuya
    Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University
  • MATSUURA Tatsuo
    Department of Clinical Research, National Minamifukuoka Chest Hospital
  • OKA Kae
    Department of Pedriatrics, Faculty of Medicine, Kurume University

Bibliographic Information

Other Title
  • 六君子湯・補中益気湯の副腎皮質機能・自律神経機能に及ぼす影響の検討
  • リックンシトウ ホチュウエッキトウ ノ フクジン ヒシツ キノウ ジリツ シ

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Description

The effects of Rikkunshi-to and Hochu-ekki-to on serum cortisol as well as on the coefficient of variation of R-R intervals of ECG (CVR-R) were studied.<br>Each drug was administered 7.5g/day for 4 weeks to 23 patients with non-ulcer dyspepsia and 18 with psychovegetative syndrome, respectively.<br>1) In the Rikkunshi-to treated patients, the serum cortisol at 9a.m. in 7 patients with a high cortisol level decreased significantly (p<0.05), but increased in 2 of the low cortisol level patients and did not change in the 14 patients who were within the normal range. In the Hochu-ekki-to treated patients, it increased in both 3 patients of the low cortisol level group and 12 of the normal range group (p<0.05), but decreased in 3 of the high cortisol level group. This modulatory effect of serum cortisol was consideredto be due to ACTH secretion.<br>2) CVR-R, which represents the parasympathetic nervous function, showed no change in the Rikkunshi-to-treated patients. However, in the Hochu-ekki-to treated patients, it increased significantly (p<0.05) in those in whom their pretreatment levels were lower than their ages.<br>These results suggest that the above drugs have modulatory effects on the adrenal cortex and autonomic nervous function. This effect is thus considered to be a beneficial one for stress-related disorders.

Journal

  • Kampo Medicine

    Kampo Medicine 43 (3), 439-446, 1993

    The Japan Society for Oriental Medicine

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