Associations between Fat Mass and Obesity-associated (FTO) Gene Polymorphism and Body Fat Accumulation and Glucose Metabolism Disorders in Japanese Females: The Effects of Endurance Training and Aging

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  • Tanaka Midori
    Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women's University
  • Wu Bin
    Open Research Center for Lifestyle-Related Disease, Mukogawa Women's University
  • Tanino Norikazu
    Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women's University Resarch Center for Elderly Nutrition and Development, Mukogawa Women's University
  • Fukuo Keisuke
    Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women's University Open Research Center for Lifestyle-Related Disease, Mukogawa Women's University Resarch Center for Elderly Nutrition and Development, Mukogawa Women's University
  • Kazumi Tsutomu
    Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women's University Open Research Center for Lifestyle-Related Disease, Mukogawa Women's University Resarch Center for Elderly Nutrition and Development, Mukogawa Women's University
  • Yoshida Toru
    Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women's University Resarch Center for Elderly Nutrition and Development, Mukogawa Women's University

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Other Title
  • 日本人女性におけるFTO遺伝子多型と体脂肪蓄積，糖代謝異常の関連―運動と加齢の影響―
  • ニホンジン ジョセイ ニ オケル FTO イデンシ タケイ ト タイシボウ チクセキ,トウ タイシャ イジョウ ノ カンレン : ウンドウ ト カレイ ノ エイキョウ

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In order to determine the impact of endurance training and aging on the effects of the FTO polymorphism with respect to body fat accumulation and glucose dysregulation, we examined four groups of females: 147 young athletes, 303 young non-athletes, 132 middle-aged females and 202 elderly females. The fat mass was measured using whole-body dual-energy X-ray absorptiometry in the young and middle-aged females and an impedance method in the elderly females. Daily energy intake was also determined in 206 young non-athlete females and 94 middle-aged females. The genotype AA was found to be associated with general adiposity, with no differences between the young athletes and non-athletes. The AA homozygote was found to be associated with fasting hyperinsulinemia in the young non-athletes, but not in the young athletes. Among the middle-aged females, the AA homozygote was also found to be associated with central adiposity and fasting hyperglycemia coupled with higher levels of HbA1c. In contrast, no associations with genotype AA were found among any of the variables studied in the elderly females. The AA homozygote was found to be associated with a greater energy intake in the young non-athletes. Our results suggest that endurance training has little influence on the effects of genotype AA with respect to general adiposity in young females. The associations observed in the young and middle-aged females with FTO polymorphism were not evident among the postmenopausal elderly females.<br>

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