Diurnal Changes in Blood Glucose in Diabetic Patients Treated with Pork and Semisynthetic Human Insulin

DOI

Bibliographic Information

Other Title
  • 糖尿病患者におけるブタモノコンポーネントインスリンと半合成ヒトモノコンポーネントインスリン製剤使用時の血糖1日曲線の比較

Search this article

Description

Diurnal changes in blood glucose were compared in diabetic patients during treatment with porcine monocomponent insulin and semisynthetic human insulin. Monotard and Actrapid preparations (Novo) were employed in these experiments. In patients whose diabetic control was stabilized with porcine insulin treatment, the diurnal blood glucose levels were examined. They were then transferred to human insulin treatment with the same doses and same preparations. After 7 days treatment, the diurnal blood glucose was again examined. In 5 patients who had one morning injection of Monotard preparation, no significant difference was detected in the diurnal blood glucose values between the periods of pork and human insulin treatment, although there was some tendency for higher blood glucose in the daytime with porcine insulin treatment and in the evening during treatment with human insulin. In patients who received two injections of Monotard plus Actrapid, there was no difference in diurnal blood glucose profiles between the two treatment periods. None of the patients had ketonuria during the study periods with both insulin. A few patients exhibited hypoglycemic reactions during human insulin treatment. Although Actrapid insulin of human origin is known to be absorbed somewhat faster than porcine Actrapid insulin, when administerd subcutaneously to healthy subjects, no evidence of any differences in time of action between Monotard of porcine and human insulin was obtained in this study.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top