Effects of Anti-Oketsu Drugs, Keishibukuryogan and Tokishakuyakusan on Platelet Aggregation in Normal Human Volunteer

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  • 健常成人における桂枝ぶく苓丸と当帰しゃく薬散の血小板凝集に対する影響
  • ケンジョウ セイジン ニ オケル ケイシブクリョウガン ト トウキシャクヤクサン ノ ケッショウバン ギョウシュウ ニ タイスル エイキョウ

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Effects of anti-oketsu drug, Keishibukuryogan (Gui-zhi-fu-ling-wan) and Tokishakuyakusan (Dang-gui-shao-yao-san) in vivo and in vitro on platelet aggregation were investigated in normal volunteers.<br>Of 20 volunteers who were given Keishibukuryogan, there were 6, 3 and 11 subjects whose dose-response curves of collagen-induced aggregations were shifted to the right, to the left, or who had no shift, respectively. The control aggregations of these 20 people were in the same range. In ADP-induced aggregation, there were 5 curves shifted to the right. Their potencies in the control aggregation were higher than those of 9 subjects who were not affected by the drug. There were 6 curves shifted to the left, and their potencies were lower than those of the 9 unaffected subjects. Of 12 volunteers who were given Tokishakuyakusan, there were 2, 2 and 8 subjects whose dose-response curves in collagen-induced aggregation were shifted to the right, the left, or who had no shift respectively. With ADP-induced aggregation, there were 1, 1 and 10 subjects whose doseresponse curves were shifted likewise. In vitro, Keishibukuryogan caused inhibition of ADP-induced aggregation but not that of collagen-induced aggregation.

Journal

  • Kampo Medicine

    Kampo Medicine 56 (4), 561-566, 2005

    The Japan Society for Oriental Medicine

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