Treatment of Spinocerebellar Degeneration with Yoku-kan-san.

DOI 1 Citations
  • OGAWA Tatsuji
    Department of Neurology, Miyagi National Hospital Iwaki Kyoritsu General Hospital
  • KIMURA Itaru
    Department of Neurology, Miyagi National Hospital

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Other Title
  • 脊髄小脳変性症に対する抑肝散の治療効果

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Description

In order to study its clinical value, Yoku-kan-san was administered for 15 days to eight patients (mean age of 59.3±11.3 years) with spinocerebellar degeneration, namely, three with olivopontocerebellar atrophy (OPCA), two with late cerebellar cortical atrophy, and three with familiar spinocerebellar degeneration. No significant changes were observed in countertapping, frequency of urination, supine blood pressure, pulse rates, or the area and distance of the sway of the center of gravity. Nor was any improvement noted in orthostatic hypotension. However, scores for activities in daily life (maximum score: 100), improved significantly from 74.8 to 81.0 (p<0.05). Six of the eight patients experienced subjective improvements such as standing or walking more steadily, relief from dizziness, and a lighter feeling in the upper extremities. Although such improvement was transient in the patients with OPCA, Kampo treatment such as Yoku-kan-san seems worth trying for spinocerebellar degeneration, as there is no other basic therapy available at the moment.

Journal

  • Kampo Medicine

    Kampo Medicine 45 (2), 359-364, 1994

    The Japan Society for Oriental Medicine

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