An Analysis of the Effect of Acarbose, A Postprandial Glucose-lowering Agent, on Postprandial Lipid Profiles after the Ingestion of A Test Meal A

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  • Kobayashi Kazuki
    Department of Regional Disaster Medicine, Chiba University Graduate School of Medicine Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine
  • Takemoto Minoru
    Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine
  • Ishikawa Takahiro
    Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine
  • Okabe Emiko
    Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine
  • Onishi Shunichiro
    Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine
  • Kuribayashi Nobuichi
    Misaki Naika Clinic

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Other Title
  • 食後血糖改善薬アカルボースの食後脂質代謝におよぼす影響―テストミールAを用いた検討―
  • 診断・治療(食事・運動・薬物) 食後血糖改善薬アカルボースの食後脂質代謝におよぼす影響 : テストミールAを用いた検討
  • シンダン ・ チリョウ(ショクジ ・ ウンドウ ・ ヤクブツ) ショクゴ ケットウ カイゼンヤク アカルボース ノ ショクゴ シシツ タイシャ ニ オヨボス エイキョウ : テストミール A オ モチイタ ケントウ

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Abstract

Postprandial hypertriglyceridemia (PPhTG) is one of the features of dyslipidemia in type 2 diabetes mellitus. PPhTG has been reported to be an independent risk factor for cardiovascular disease that is distinct from fasting hTG. Twenty patients with type 2 diabetes mellitus who showed PPhTG as their main condition, were treated with 300 mg/day of acarbose (an alpha-glucosidase inhibitor) for three months to assess the effect of acarbose on PPhTG. Following the treatment, the patients' postprandial metabolic parameters were evaluated 2 hours after the ingestion of a test meal in the morning. After the treatment, bodyweight, HbA1c and postprandial triglyceride (PPTG) levels were significantly reduced. There was a significant negative association between the level of PPTG before the treatment and the changes to PPTG and apoprotein B48 (ApoB48) levels after the treatment. Furthermore, postprandial ApoB48 was significantly reduced by the treatment in only13 patients who showed over 150 mg/dl of PPTG, which could be defined as PPhTG. These results suggested that acarbose treatment could be useful for reducing postprandial hyperglycemia in type 2 diabetes patients through the suppressive effect seen in the extrinsic lipid metabolism, which can be evaluated by serum ApoB48.

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