Effect of Keishibukuryogan on Silent Brain Infarction over 3 Years

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  • GOTO Hirozo
    Department of Japanese Oriental (Kampo) Medicine, Faculty of Medicine, University of Toyama 21st Century COE Program, University of Toyama
  • SHIMADA Yutaka
    Department of Japanese Oriental (Kampo) Medicine, Faculty of Medicine, University of Toyama 21st Century COE Program, University of Toyama
  • HIKIAMI Hiroaki
    Department of Japanese Oriental (Kampo) Medicine, Faculty of Medicine, University of Toyama
  • KOBAYASHI Shotai
    Department of Internal Medicine III, Faculty of Medicine, Shimane University
  • YAMAGUCHI Shuhei
    Department of Internal Medicine III, Faculty of Medicine, Shimane University
  • MATSUI Ryukichi
    Department of Internal Medicine III, Faculty of Medicine, Shimane University
  • SHIMODE Kohichi
    Hikawa Central Clinic
  • MITSUMA Tadamichi
    Department of Japanese Oriental (Kampo) Medicine, Oriental Medical Center, Iizuka Hospital
  • SHINTANI Takahiro
    Research Institute of Oriental Medicine, Kinki University
  • NINOMIYA Hiroyuki
    Department of Japanese Oriental (Kampo) Medicine, Kanebo Memorial Hospital
  • NIIZAWA Atsushi
    Department of Japanese Oriental (Kampo) Medicine, Kanebo Memorial Hospital
  • NAGASAKA Kazuhiko
    Department of Japanese Oriental (Kampo) Medical Center, Suwa Central Hospital
  • SHIBAHARA Naotoshi
    21st Century COE Program, University of Toyama Department of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama
  • TERASAWA Katsutoshi
    Department of Japanese Oriental (Kampo) Medicine, Graduate School of Medicine, Chiba University

Bibliographic Information

Other Title
  • 無症候性脳梗塞に対する桂枝茯苓丸の3年間投与後の効果

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Description

The purpose of this study was to evaluate the effect of keishibukuryogan (KB) against the cognitive symptoms associated with silent brain infarction in a prospective cohort study. The subjects were 93 patients with silent brain infarcts who visited the Department of Japanese Oriental Medicine, University of Toyama, and its allied hospitals. They consisted of 24 males and 69 females, mean age (± S.E.) 70.0±0.8.Group SK (n=51) consisted of patients who used KB extract for more than6months per year. Group SC (n=42) consisted of patients who did not use Kampo formulas. The NS group (n=44) consisted of elderly subjects who had no silent brain infarction, 21 males and 23 females, with a mean age (± S.E.) of 70.7±0.7 years. Among the three groups, the revised version of Hasegawa's dementia scale, apathy scale and self-rating depression scale were compared between the study start and after three years. In the SK and SC groups, these scores, and the subjective symptom levels (head heaviness, headache, dizziness or vertigo, stiff shoulder) were also studied. The results showed that the self-rating depression scales at study start for the SK and SC groups were significantly higher compared to the NS group. In spite of the scores for the NS group increasing after three years, the SK group scores were significantly decreased compared to the SC and NS groups. KB was effective against head heaviness, which often complicates silent brain infarction. In the above mentioned, KB was effective in treating cognitive disorders and subjective symptoms related to silent brain infarction.

Journal

  • Kampo Medicine

    Kampo Medicine 59 (3), 471-476, 2008

    The Japan Society for Oriental Medicine

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