末期肝不全患者に見られた遅発性溶血性輸血副作用様症状と同時に検出された抗Ｅｎ｀ａ´について
書誌事項
- タイトル別名
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- Anti-Ena in a case of delayed hemolytic transfusion reaction.
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説明
We experienced a patient with a life-threatening suspected delayed hemolytic transfusion reaction (DHTR). The patient was a 73-year-old female with liver cirrhosis. Her blood type was A+, D+C-c+E+e-. She had has 2 pregrancies and a history of 2 transfusions. She received 1 unit of whole blood and 2 units of concentrated red cells for the treatment of anemia (Hb 7.1g/dl) on December 2 and 3, 1992.<br>No irregular antibodies were found before transfusion and crossmatch test showed no significant agglutination by the indirect antiglobulin test. Her hemoglobin level dropped to 1.4g/dl between the day 7 to the day 9 after transfusion without any bleeding signs. At the same time GOT, LDH and T. Bil. levels, increased remarkably. However, no hematuria was seen hematuria. Serological studies showed the presence of strong antibodies against high frequency red cell antigen. The antibody was identified as anti-Ena, which is associated with the MNS blood system. Anti-Ena titer increased 16 to 256 times by the saline method, and 256 to 64, 000 times by the indirect antiglobulin test from the day 9 to day 12 after transfusion. These findings strongly suggested DHTR secondary response. The elution test using cells from her elder sister (also En (a-)) showed the existence of anti-C and anti-e. It is therefore difficult to identify the antibody responsible for the DHTR. Reports of anti-Ena are rare, this being only the second case reported in the Japanese literature.
収録刊行物
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- 日本輸血学会雑誌
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日本輸血学会雑誌 42 (6), 289-293, 1996
一般社団法人 日本輸血・細胞治療学会
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詳細情報 詳細情報について
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- CRID
- 1390282679885762944
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- NII論文ID
- 130003853072
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- ISSN
- 18838383
- 05461448
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- 抄録ライセンスフラグ
- 使用不可