Proposal of Diagnostic Criteria for Acute-onset Type 1 Diabetes Mellitus (2012) -Report of the Committee of the Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 Diabetes Mellitus-

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  • Kawasaki Eiji
    Department of Metabolism/Diabetes and Clinical Nutrition, Nagasaki University Hospital
  • Maruyama Taro
    Department of Internal Medicine, Saitama Social Insurance Hospital
  • Imagawa Akihisa
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
  • Awata Takuya
    Department of Endocrinology and Diabetes, Saitama Medical University
  • Ikegami Hiroshi
    Department of Endocrinology, Metabolism and Diabetes, Kinki University School of Medicine
  • Uchigata Yasuko
    Diabetes Center, Tokyo Women's Medical University School of Medicine
  • Osawa Haruhiko
    Department of Laboratory Medicine, Ehime University School of Medicine
  • Kawabata Yumiko
    Department of Endocrinology, Metabolism and Diabetes, Kinki University School of Medicine
  • Kobayashi Tetsuro
    Third Department of Internal Medicine, University of Yamanashi
  • Shimada Akira
    Department of Internal Medicine, Saiseikai Central Hospital
  • Shimizu Ikki
    Department of Internal Medicine, The Sakakibara Heart Institute of Okayama
  • Takahashi Kazuma
    Department of Diabetes and Metabolism, Iwate Medical University
  • Nagata Masao
    Department of Internal Medicine, Kakogawa West City Hospital
  • Makino Hideichi
    Diabetes Center, Shiraishi Hospital
  • Hanafusa Toshiaki
    Department of Internal Medicine (I), Osaka Medical College Chairman

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Other Title
  • 急性発症1型糖尿病の診断基準（2012）の策定―1型糖尿病調査研究委員会（劇症および急性発症1型糖尿病分科会）報告―
  • 委員会報告 急性発症1型糖尿病の診断基準(2012)の策定 : 1型糖尿病調査研究委員会(劇症および急性発症1型糖尿病分科会)報告
  • イインカイ ホウコク キュウセイ ハッショウ 1ガタ トウニョウビョウ ノ シンダン キジュン(2012)ノ サクテイ : 1ガタ トウニョウビョウ チョウサ ケンキュウ イインカイ(ゲキショウ オヨビ キュウセイ ハッショウ 1ガタ トウニョウビョウ ブンカカイ)ホウコク

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Type 1 diabetes is characterized by the destruction of pancreatic beta cells, which leads to an absolute deficiency in insulin secretion. Depending on the manner of onset and progression, the disease is classified as fulminant, acute or slowly progressive. We herein propose diagnostic criteria for acute-onset type 1 diabetes mellitus. Among patients who develop ketosis or diabetic ketoacidosis within three months after the onset of hyperglycemic symptoms and require insulin treatment continuously after the diagnosis of diabetes, those with anti-islet autoantibodies are diagnosed with "acute-onset type 1 diabetes mellitus (autoimmune)." On the other hand, those whose endogenous insulin secretion is exhausted (a fasting CPR level of <0.6 ng/ml) without verifiable anti-islet autoantibodies are diagnosed simply with "acute-onset type 1 diabetes mellitus." Patients should therefore be reevaluated after certain periods in cases in which the status of anti-islet autoantibodies and/or endogenous insulin secretion is unknown.<br>

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