A Case of Sleep Apnea Syndrome Improved after Administration of Hange-koboku-to.

DOI 3 Citations 9 References
  • HISANAGA Akito
    Furusato Hospital
  • ITOH Takashi
    Deparment of Kampo Diagnostics, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
  • NIIZAWA Atsushi
    Department of Japanese Oriental (Kampo) Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University
  • YOKOYAMA Koichi
    Department of Japanese Oriental (Kampo) Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University
  • KITA Toshiaki
    Deparment of Kampo Diagnostics, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
  • TERASAWA Katsutoshi
    Department of Japanese Oriental (Kampo) Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University

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Other Title
  • 半夏厚朴湯が有効であった睡眠時無呼吸症候群の１例

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Description

We report a case of obstructive sleep apnea syndrome effectively treated with Hange-koboku-to. A 32-year-old male suffered from globus syndrome (globus hystericus), excessive daytime sleepiness and snoring. He underwent uvulopalatopharyngoplasty at the age of 27, but the symptoms did not improve after surgery. Nocturnal polysomnography, performed before administration of Hange-koboku-to, confirmed the diagnosis of obstructive sleep apnea syndrome. After 1-month-administration of Hange-koboku-to extract (Tsumura Co. Ltd., 7.5g/day), his complaints almost disappeared. After 5-month-administration of Hange-koboku-to, nocturnal polysomnography was performed again. As a result, the apnea index fell from 19.2 events/hour to 10.3 events/hour, and the apnea-hypopnea index also fell from 19.2 events/hour to 12.8 events/hour. He was not obese (body mass index: 23.0kg/m2), and no significant body weight change was observed after administration. No adverse effect was observed. To our knowledge, there is no other report on the treatment of sleep-related breathing disorders with Hange-koboku-to. We presume that Hange-koboku-to may decrease the upper airway resistance, especially at the lower part of the upper airway.

Journal

  • Kampo Medicine

    Kampo Medicine 52 (4/5), 501-505, 2002

    The Japan Society for Oriental Medicine

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