書誌事項
- タイトル別名
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- A Patient with Decreasing Secretion of Endogenous Insulin Associated with the Appearance of Low Titer Anti-GAD Antibodies Fifteen Years after the Initial Diagnosis of Diabetes
- ショウレイ ホウコク 15ネン ノ 2ガタ トウニョウビョウ ノ ケイカ チュウ,コウGAD コウタイ ガ 10カゲツ テイチ ヨウセイ ト ナリ インスリン ブンピ テイカ オ キタシテ イル 1レイ
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A 56-year-old female was diagnosed with type 2 diabetes mellitus 15 years ago and had been treated with several oral hypoglycemic agents, but her glycemic control was poor. She was admitted to our hospital yearly and always showed negative results for anti-GAD antibodies (GADAb). At her last admission, she had a low titer of GADAb (4.6 U/ml), and insulin therapy was started. At that point, her urinary C-peptide level was 77 μg/day. Ten months later, she was admitted to our hospital again, and her laboratory data showed the following: HbA1c level, 9.7 %; serum C-peptide levels after fasting and 2 h after breakfast, 0.7 ng/ml and 2.1 ng/ml, respectively; mean urinary C-peptide level, 18.5 (22.1/14.8) μg/day; increase in the serum C-peptide level six minutes after the intravenous loading of glucagon (1 mg), 1 ng/ml; and the titer of GADAb, 1.2 U/ml. In the current case, the titer of GADAb was initially low, and its positive period was short, last only 10 months. During this period, the endogenous insulin secretion decreased remarkably. Based on these findings, it was thought that the decrease of insulin secretion in this case was associated with an autoimmune mechanism.<br>
収録刊行物
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- 糖尿病
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糖尿病 56 (1), 31-36, 2013
一般社団法人 日本糖尿病学会
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詳細情報 詳細情報について
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- CRID
- 1390282679886155392
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- NII論文ID
- 10031170448
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- NII書誌ID
- AN00166576
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- ISSN
- 1881588X
- 0021437X
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- NDL書誌ID
- 024270353
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可