Statistical Analysis of the Findings in Patients Responded to Goshuyuto

DOI Web Site 10 References
  • ODAGUCHI Hiroshi
    Department of Oriental Medicine, Doctoral Program of Medical Science, Kitasato University Graduate School Department of Clinical Research, Oriental Medicine Research Center of the Kitasato Institute
  • WAKASUGI Akino
    Department of Oriental Medicine, Doctoral Program of Medical Science, Kitasato University Graduate School Department of Clinical Research, Oriental Medicine Research Center of the Kitasato Institute
  • Ito Hidenori
    Department of Oriental Medicine, Doctoral Program of Medical Science, Kitasato University Graduate School Department of Clinical Research, Oriental Medicine Research Center of the Kitasato Institute
  • Shoda Hisakazu
    Department of Oriental Medicine, Doctoral Program of Medical Science, Kitasato University Graduate School Department of Clinical Research, Oriental Medicine Research Center of the Kitasato Institute
  • Gono Yukari
    Department of Clinical Research, Oriental Medicine Research Center of the Kitasato Institute
  • Kim Sung-Joon
    Department of Clinical Research, Oriental Medicine Research Center of the Kitasato Institute
  • Endo Mari
    Department of Clinical Research, Oriental Medicine Research Center of the Kitasato Institute
  • Oikawa Tetsuroh
    Department of Clinical Research, Oriental Medicine Research Center of the Kitasato Institute
  • Sakai Fumihiko
    Department of Neurology, Kitasato University
  • Hanawa Toshihiko
    Department of Oriental Medicine, Doctoral Program of Medical Science, Kitasato University Graduate School Department of Clinical Research, Oriental Medicine Research Center of the Kitasato Institute

Bibliographic Information

Other Title
  • 呉茱萸湯responderの漢方医学的所見に関する統計学的検討

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Description

The purpose of this study was to reevaluate the sho of goshuyuto, which has been established in an unscientific manner, and to create a new concept of the sho of goshuyuto. Eighty-four patients suffering from chronic headache were instructed to orally consume 7.5g. day of a spray-dried powder of goshuyuto (TJ-31) for 4 weeks. Before consuming the TJ-31, all subjects underwent Kampo examinations that were based on 43 diagnostic items. After the 4-week period of medication, all the subjects were classified as either responders or nonresponders. After excluding insignificant items from the 43 diagnostic items, discriminant analysis, which discriminated between responders and nonresponders, was conducted. Of the 80 subjects who completed the trial period, 57 were judged to be responders and 23 to be nonresponders. “Cold feet,” “fluid and gas retention in the stomach,” “kyokyo-kuman,” “tenderness at side of navel,” and “pulsation at abdomen” were selected by stepwise selection. The results of the discriminant analysis using these 5 items suggest that 28 subjects were misclassified and that the misclassification rate was 35%. Of the actual 23 nonresponders, 20 were accurately discriminated as nonresponders. The 5 selected items are suggested to be more useful in selecting the nonresponders than the responders. In conclusion, the empirically established sho of goshuyuto seemed to not be abele to completely explain the indication of goshuyuto. However, the inclusion of “tenderness at side of navel” and “pulsation at abdomen,” as new components comprising the sho of goshuyuto, may facilitate a more accurate indication of goshuyuto.

Journal

  • Kampo Medicine

    Kampo Medicine 58 (6), 1099-1105, 2007

    The Japan Society for Oriental Medicine

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