<b>A Case of Refractory Transient Ischemic Attack Successfully Managed with C</b><b>hotosan</b>

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  • <b>西洋薬治療に抵抗性を示し釣藤散が著効した</b><b>頻回の一過性脳虚血発作の1例</b>
  • 臨床報告 西洋薬治療に抵抗性を示し釣藤散が著効した頻回の一過性脳虚血発作の1例
  • リンショウ ホウコク セイヨウヤク チリョウ ニ テイコウセイ オ シメシ ズリ フジサン ガ チョコウシタ ヒンカイ ノ イッカセイ ノウキョケツ ホッサ ノ 1レイ

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Abstract

<p>We report a case of refractory transient ischemic attack (TIA) successfully treated with chotosan. A 64-year-old woman with recurrent right hemiparesis and dysarthria was seen in our clinic. Twenty-three months before coming to our clinic, she had a history of right hemiparesis and dysarthria, which resolved soon after treatment. Magnetic resonance imaging (MRI) revealed an ischemic legion in the left corona radiata. Then 4 months before coming, she had repeated transient right hemiparesis and dysarthria, which lasted for 40 to 50 minutes and recurred 3 to 4 times a week. She was hospitalized and treated with an intensive TIA therapy including direct thrombin inhibitor, dual antiplatelet therapy, statin, calcium channel blocker and benzodiazepine. Though she continued the therapy for 4 months, it proved ineffective. She was referred to our clinic, and we started to administer chotosan 7.5 g per day for anxiety and dizziness during an attack. Chotosan attenuated TIA within a week, but aggravated after discontinuation on her own. The medication was resumed and TIA diminished within three months. Chotosan treatment has now been continued for 17 months without a single TIA for 14 months. Multiple studies have shown the protective effect of chotosan against cerebrovascular diseases including cerebral infarction and TIA. Therefore, chotosan may be an effective prescription for refractory TIA.</p>

Journal

  • Kampo Medicine

    Kampo Medicine 68 (4), 345-351, 2017

    The Japan Society for Oriental Medicine

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