Vancomycin TDM and Supporting Renal Functions for Dosage Planning.

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  • 投与量モニタリングによるバンコマイシン投与計画の支援
  • トウヨリョウ モニタリング ニ ヨル バンコマイシン トウヨ ケイカク ノ シ

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As members of the hospital acquired infection study committee, we expsained the necessty of Vancomycin (VCM) Therapeutic Drug Monitoring (TDM) and proposed to establish a VCMTDM system in our hospital.<BR>At first, the physicians decided to treat the patients with antiseptic-resistant strains of methicillin-resistant Staphlococcus aureus (MRSA) in combination with VCM.<BR>We determined the loading dose, dosing interval and points of drawing blood, and inform the doctors of these data. Pharmacokinetic parameters were determined using a one-compartment model. We consulted the doctors on the individualization of dosage regimen.<BR>So, to avoid renal failure, it is important to measure serum VCM concentration and to adjust the dose and dosing interval, after prescribing the estimated dose. In three case reports, patients could avoid adverse effects such as renal failure. Dose adjustment based on VCM serum concentration was necessary.

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