Changes in Pancreatic Secretory Trypsin Inhibitor after Hepatic Resections.

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  • 肝切除後のすい分泌性トリプシンインヒビターの変動

Abstract

Pancreatic seretory trypsin inhibitor (PSTI) is an endogenous trypsin inhibitor and is also known as an acute phase reactant. However, its role and function has not been fully understood. Twenty-nine patients who underwent hepatic resections were divided into two groups. Group A: patients whose postoperative course were uneventful (n: 19). Group B: patients who developed postoperative complication after hepatectomies (n: 10). PSTI was measured with the radioiommunoassay before the operation and on the 2nd, 4th, 7th, 14th, 21st and 28th postoperative day. Postoperative patients were also evaluated by conventional liver function test (sGOT, sGPT etc.) PSTI was normal in all patients before the operation. We noticed the increase of PSTI in all patients who underwent hepatic resections and who developed postoperative complications after hepatectomies. There was a significant correlation between PSTI on the 4th postoperative day and the duration of the operation. PSTI is the index to evaluate degrees of surgical stress. And there was a significant correlation between the PSTI on the 4th postoperative day and both preoperative ICGRlS and preoperative hepaplastin test. Postoperative elevation of PSTI depends not only on the surgical stress but also on the hepatic function.

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