Laparoscopic Cholecystectomy Safely Performed for a Patient with Cold Agglutinin Disease

  • Hata Hiroaki
    Department of Surgery, National Hospital Organization, Kyoto Medical Center
  • Iwama Hideaki
    Department of Surgery, National Hospital Organization, Kyoto Medical Center
  • Okuchi Yoshihisa
    Department of Surgery, National Hospital Organization, Kyoto Medical Center
  • Nishikawa Gen
    Department of Surgery, National Hospital Organization, Kyoto Medical Center
  • Ogiso Satoshi
    Department of Surgery, National Hospital Organization, Kyoto Medical Center
  • Yamaguchi Takashi
    Department of Surgery, National Hospital Organization, Kyoto Medical Center
  • Otani Tetsushi
    Department of Surgery, National Hospital Organization, Kyoto Medical Center
  • Tsuchiya Nobuyuki
    Department of Surgery, National Hospital Organization, Kyoto Medical Center
  • Yamato Toshio
    Department of Surgery, National Hospital Organization, Kyoto Medical Center
  • Koizumi Kinya
    Department of Surgery, National Hospital Organization, Kyoto Medical Center

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Other Title
  • 寒冷凝集素症患者に対し安全に腹腔鏡下胆嚢摘出術を施行しえた1例

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A 75-year-old man with cold agglutinin disease (CAD) who had undergone laparoscopic cholecystectomy was admitted for jaundice and fever, diagnosed as cholelithiasis and choledocolithiasis, and cholecystectomy was planned. CAD is a form of autoimmune hemolytic anemia. Autoantibodies, usually immunoglobulin M, cause red blood cell agglutination and hemolysis at a decreased body temperature. Because perioperative hypothermia is by far the most common perioperative thermal disturbance, special consideration is required in surgical subjects with CAD. Our perioperative approach was to (1) treat CAD medically, (2) avoid a cool environment, (3) consider plasmapheresis, (4) administer erythropoietin, (5) prepare for transfusion, and (6) keep the body temperature to 37°C. These procedures, excluding plasmapheresis, enabled us to safely conduct laparoscopic cholecystectomy for a subject having CAD.

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