ラット自発運動の生体防御機構に及ぼす慢性影響

DOI Web Site Web Site 被引用文献3件 オープンアクセス
  • 鈴木 克彦
    早稲田大学人間科学部衛生学公衆衛生学教室
  • 町田 和彦
    早稲田大学人間科学部衛生学公衆衛生学教室
  • 刈屋 美枝子
    早稲田大学人間科学部衛生学公衆衛生学教室
  • 有倉 恵子
    早稲田大学人間科学部衛生学公衆衛生学教室
  • 稲 恭宏
    早稲田大学人間科学部衛生学公衆衛生学教室
  • 塚本 和正
    早稲田大学人間科学部衛生学公衆衛生学教室

書誌事項

タイトル別名
  • CHRONIC EFFECTS OF VOLUNTARY EXERCISE ON SRBC-INDUCED HOST DEFENSE REACTIONS IN RATS
  • ラット ジハツ ウンドウ ノ セイタイ ボウギョ キコウ ニ オヨボス マンセ

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説明

A study was conducted to evaluate the chronic effects of regular physical activity on nonspecific and specific immune responses. Male Fischer rats (SPF) exercised voluntarily on running wheels for 4 months, and were then injected intraperitoneally with sheep red blood cells (SRBC), followed by measurement of the host defense functions at -2 d, 3h, 24h and 4 d of antigen stimulation. The following results were obtained:<BR>1) The ability of circulating neutrophils to produce superoxide measured by the spontaneous NBT test showed an earlier and higher (p<0.05) rise after SRBC injection in the exercise group, suggesting that neutrophils were activated in vivo more promptly against foreign-body invasion. This might reflect a priming response of neutrophils at the early phase of SRBC-induced host defense reactions modulated by the previous regular exercise.<BR>2) The ability of neutrophils to produce superoxide in response to in vitro stimulation with Staphylococcus aureus 209 P was markedly reduced during inflammatory response in the sedentary group, whereas that in the exercise group was maintained at a constant level. The value at 4 d after SRBC injection in the sedentary group was decreased to more than 20% below the baseline (p<0.02) . In addition, a significantly (p<0.02) lower value than that in the exercise group was shown, although phagocytic activity was similar in the two groups. This suggested that neutrophil bactericidal activity was decreased in the sedentary group.<BR>3) Plasma IgG levels in the exercise group were consistently and significantly (p<0.0001) higher by about 30% than those in the sedentary group, regardless of SRBC injection. This suggested an enhanced host defense status by regular exercise.<BR>4) The specific humoral immune response to SRBC injection was assessed in terms of hemagglutination and plasma IgM levels, but no significant differences were shown between the groups.

収録刊行物

  • 体力科学

    体力科学 42 (2), 145-154, 1993

    一般社団法人日本体力医学会

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