Inhibition of malaria infection and repellent effect against mosquitoes by chlorine dioxide

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  • 二酸化塩素によるマラリア感染防止効果と蚊に対する忌避作用

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We examined whether chlorine dioxide (ClO2) could inhibit malaria infections when applied to the skin. Anesthetized mice were divided into two groups: one group was sprayed with ClO2 solution and the other with distilled water. Each mouse was then placed on a vessel housing malaria-infected mosquitoes. The proportion of mosquitoes that fed on mice sprayed with distilled water was 47.7% (42/88) and the proportion of malaria-infected mice was 54.5% (6/11). These values were 5.9% (6/101) (p<0.01) and 7.7% (1/13) (p<0.05) in ClO2-sprayed mice. In a separate experiment, mosquitoes (Anopheles stephensi, Culex pipiens pallens and Aedes albopictus) were placed in a mesh-covered tube with an air-containing box at one end and a ClO2-containing box at the other. Mosquitoes were more likely to stay at the side facing the air-containing box, which indicated that they avoided ClO2 gas at concentrations as low as 0.03 ppm. ClO2 spray and gas could be used as a mosquito-repellent and may also reduce the transmission of malaria.

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