Determination of biogenic amines in spider venom glands of nine typical Japanese species and chromatographic elution pattern analysis of venomous components

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  • HAGIWARA Kenichi
    Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, The University of Tokyo
  • TOKITA Akiko
    Department of Environmental Biology, Faculty of Environmental Health Azabu University
  • MIWA Akiko
    Department of Neurobiology, Tokyo Metropolitan Institute for Neurosciences
  • KAWAI Nobufumi
    Department of Neurobiology, Tokyo Metropolitan Institute for Neurosciences
  • MURATA Yoshihiko
    Department of Environmental Biology, Faculty of Environmental Health Azabu University
  • UCHIDA Akihiko
    Department of Environmental Biology, Faculty of Environmental Health Azabu University
  • NAKAJIMA Terumi
    Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, The University of Tokyo

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Other Title
  • 日本産クモ毒腺中の生物活性アミンの定量および液体クロマトグラフィーによる毒成分の比較
  • 日本産クモ毒腺中の生物活性アミンの定量および液体クロマトグラフィーによる毒成分の比較〔英文〕
  • ニホンサン クモ ドクセンチュウ ノ セイブツ カッセイ アミン ノ テイリョ

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Abstract

Catecholamine and polyamine as well as serotonin and histamine contained in spider venom glands of nine typical Japanese species were quantified. Spider venoms generally appeared poor in either catecholamine and serotonin but rich in polyamine. However, only Chiracanthium japonicum was distinguishable since large amounts of norepinephrine, epinephrine and serotonin were contained. We also examined chromatographic elution patterns of the venomous substances by using high performance liquid chromatography with a reversed-phase column, and found that a venom fraction from the spiders belonging to genus Agelena blocked lobster neuromuscular synapse in an irreversible manner.

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