Glucose Tolerance Test (GTT) and Serum C-peptide Immunoreactivity (CPR) in Pregnant Women
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- YOSHIDA Masumi
- Department of Obstetrics and Gynecology, Kitano Hospital
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- KITAGAWA Michio
- Department of Obstetrics and Gynecology, Kitano Hospital
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- ANDO Nobuya
- Department of Obstetrics and Gynecology, Kitano Hospital
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- SHIMOMURA Torao
- Department of Obstetrics and Gynecology, Kansaidenryoku Hospital
Bibliographic Information
- Other Title
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- 妊婦のGTTとC-peptide反応(CPR)
- ニンシン ノ GTT ト C peptide ハンノウ CPR
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Description
Generally diabetes mellitus is diagnosed by GTT and insulin response. However, C-peptide may be better parameter in diabetic patients treated with insulin, because insulin antibody interferes with the measurement of endogenous insulin. Our study was carried out from April to August in 1977 on 31 cases of non-pregnant women and 84 cases of pregnant women who had glycosuria, family history of diabetes mellitus or large babies more than 4 kilograms, all cases exclusive of patients in insulin therapy. In these women, oral glucose tolerance test with 50 grams of glucose was performed on fasting early in the morning and the levels of blood sugar (BS) and serum C-peptide irnmunoreactivity (CPR) were determined before and at 30, 60 and 120min. after administration of glucose.<br>Results<br>1) In pregnant women, the time of the maximal CPR response was at 60min. in normal type of GTT, at 60 or 120min. in borderline type and at 120min. in diabetic type.<br>2) The ΔCPR/ΔBS at 30min. is more useful to evaluate diabetes mellitus, because the mean value of 30min, has smaller standard deviation compared with that of 60 min.<br>3) In the 3 groups of patients, the difference of the ΔCPR/ΔBS at 30min. was not significant between normal and borderline type, but significant between borderline and diabetic type statistically. The diagnostic criteria of ΔCPR/ΔBS (30min.) is proposed to be 0.07 for assessment of carbohydrate metabolism.<br>4) There was no characteristic of CPR response to each group.<br>5) A significant correlation was found between ΔCPR/ΔBS and ΔIRI/ΔBS (30min.) (Y=12.4X-0.051, r=0.768), IRI being measured simultaneously.
Journal
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- ADVANCES IN OBSTETRICS AND GYNECOLOGY
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ADVANCES IN OBSTETRICS AND GYNECOLOGY 31 (6), 619-625, 1979
THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN
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Details 詳細情報について
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- CRID
- 1390282679922922752
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- NII Article ID
- 130004069478
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- NII Book ID
- AN00099490
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- ISSN
- 13476742
- 03708446
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- NDL BIB ID
- 2203377
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed