いわゆる“乗り物酔い”防止薬に関する検討　　スコポラミンの相乗効果について

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  • An appraisal of antimotion sickness drug
  • スコポラミンの相乗効果について

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A study comparing the efficacy of an anti-motion sickness drug, Scopolamine, when administered in combination with an antihistaminic drug is presented. The possibility of classifying the subjects into two groups i. e. with vulnerability to or tolerance for motion sickness is also discussed.<BR>The subjects in this study were young students who had a normal vestibular function. Three groups of 10 subjects each were used and the following drugs were evaluated.<BR>1. Dimenhydrinate, 50 mg.<BR>2. Diphenhydramine salicylate, 40mg.<BR>3. Scopolamine hydrobromide, 0.1mg and dimenhydrinate, 50mg.<BR>Each group received the acceleration and deceleration rotation testy and the sum of the values of the theoretical threshold (expressed by the angular deviation of the cupulaendolymph system) for the clockwise and counterclockwise rotation is evaluated after drug administration. The following items were pointed out in this study.<BR>1. When a combination of dimenhydrinate and scopolamine was used, a large increase in effectiveness in preventing motion sickness was suggested.<BR>2. Subjects vulnerable to motion sickness were differentiated from the normal subjects with their lower values than theoretical threshold value of 1.44°. This vulnerable group is more susceptible to the antimotion sickness drugs in the above mentioned combination than the other tolerant group.

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