A case of primary small cell carcinoma of the vagina treated with surgery and adjuvant chemotherapy

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  • MAJIMA Megumi
    Department of Obstetrics and Gynecology, Kyoto First Red Cross Hospital
  • YAMADA Toshio
    Department of Obstetrics and Gynecology, Kyoto First Red Cross Hospital
  • KATO Seiko
    Department of Obstetrics and Gynecology, Kyoto First Red Cross Hospital
  • OGISO Nozomi
    Department of Obstetrics and Gynecology, Kyoto First Red Cross Hospital
  • YAMAGUCHI Natsuko
    Department of Obstetrics and Gynecology, Kyoto First Red Cross Hospital
  • TOMITA Junko
    Department of Obstetrics and Gynecology, Kyoto First Red Cross Hospital
  • YAMAMOTO Hiroyuki
    Department of Obstetrics and Gynecology, Kyoto First Red Cross Hospital
  • URATA Yoji
    Department of Pathology, Kyoto First Red Cross Hospital
  • OKUBO Tomoharu
    Department of Obstetrics and Gynecology, Kyoto First Red Cross Hospital

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Other Title
  • 手術および補助化学療法を行った腟小細胞癌の1例
  • 症例報告 手術および補助化学療法を行った腟小細胞癌の1例
  • ショウレイ ホウコク シュジュツ オヨビ ホジョ カガク リョウホウ オ オコナッタ チツショウサイボウガン ノ 1レイ

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Abstract

Primary small cell carcinoma of the vagina is a rare, poor prognostic disease and only 29 cases have been reported so far. We here report a case of a 70 year-old, gravid 7, para 2 woman diagnosed with primary vaginal small cell carcinoma, who underwent surgery and adjuvant chemotherapy. She presented with atypical genital bleeding to a home doctor. A thumb -sized tumor was found in the vaginal wall. The patient was referred to our hospital for further examination. On examination, this tumor originated from the vaginal wall at the 9 o’clock position, in the upper one-third vaginal portion. The uterine cervix was shown to be intact. Two-thirds of the tumor was removed in the pelvic examination. The tumor consists of solid growth of small cells showing positive immunohistochemical staining for chromogranin A, synaptophysin and CD56. Magnetic resonance imaging showed a 6×11×15 mm sized tumor on the right side of the posterior vaginal wall. Computed tomography showed metastasis to the sacral and right obturatorius lymph node. Recognition of metastasis to the sacral and right obturatorious lymph node in the radical hysterectomy let us to give her five couses of adjuvant chemotherapy using etoposide and CDDP. Twenty five months has passed since the patient underwent the surgery and adjuvant chemotherapy, she has had no relapse or tumor recurrence. [Adv Obstet Gynecol, 66 (1) : 24-29, 2014 (H26. 2)]

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