A Case of Fisher Syndrome with Bilateral Horizontal Gaze Nystagmus in the Abducent Direction

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  • Iwasawa Takashi
    Department of otorhinolaryngology and head and neck surgery, Tokyo medical university Hachioji medical center
  • Nomoto Masaki
    Department of otorhinolaryngology and head and neck surgery, Tokyo medical university Hachioji medical center
  • Ogawa Yasuo
    Department of otorhinolaryngology and head and neck surgery, Tokyo medical university Hachioji medical center
  • Kondo Takahito
    Department of otorhinolaryngology and head and neck surgery, Tokyo medical university Hachioji medical center
  • Yatomi Masanori
    Department of otorhinolaryngology and head and neck surgery, Tokyo medical university Hachioji medical center
  • Katsube Yasuaki
    Department of otorhinolaryngology and head and neck surgery, Tokyo medical university Hachioji medical center
  • Takeda Atsuo
    Department of otorhinolaryngology and head and neck surgery, Tokyo medical university
  • Inoue Aya
    Department of neurology, Tokyo medical university Hachioji medical center
  • Tsukahara Kiyoaki
    Department of otorhinolaryngology and head and neck surgery, Tokyo medical university

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Other Title
  • 外転眼に注視方向性水平性眼振がみられた Fisher 症候群の1例

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<p>　Miller Fisher syndrome (MFS) was first described in 1956 by Miller Fisher as an unusual variant of acute idiopathic polyneuritis. It is a variant of Guillain-Barre syndrome that is characterized by ophthalmoplegia, ataxia, and areflexia. High titers of serum IgG reactivity to GQ1b ganglioside are detected in patients with MFS. Here, we report the case of a patient who exhibited horizontal nystagmus on the lateral gaze position early in the onset and was diagnosed with MFS.</p><p></p><p>　A 45-year-old woman was admitted to our hospital with rotatory vertigo 12 days after being diagnosed with an influenza A infection. Two days after hospitalization, she showed bilateral horizontal gaze nystagmus in the abducent direction. At the same time, a central nerve system disorder was suspected as a result of neurotological findings; she was diagnosed with MFS. The vertigo improved after the administration of intravenous immunoglobulin therapy and she was discharged 11 days after hospitalization. This is a rare case of MFS after influenza A infection. There may be an association between anti-GQ1b antibodies and peripheral or brainstem disorders.</p>

Journal

  • Equilibrium Research

    Equilibrium Research 77 (1), 11-16, 2018

    Japan Society for Equilibrium Research

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