前庭水管拡大症を伴う<I>SLC26A4</I>, <I>ATP6V1B1</I>, <I>SIX1</I>変異例の聴平衡覚所見の検討

DOI 被引用文献2件 参考文献68件 オープンアクセス
  • 野口 佳裕
    東京医科歯科大学耳鼻咽喉科
  • 伊藤 卓
    東京医科歯科大学耳鼻咽喉科 Molecular Biology and Genetics Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
  • 川島 慶之
    東京医科歯科大学耳鼻咽喉科 土浦協同病院耳鼻咽喉科
  • 西尾 綾子
    東京医科歯科大学耳鼻咽喉科
  • 本田 圭司
    東京医科歯科大学耳鼻咽喉科
  • 喜多村 健
    東京医科歯科大学耳鼻咽喉科

書誌事項

タイトル別名
  • Audiovestibular findings in patients with enlargement of the vestibular aqueduct caused by mutations of <I>SLC26A4</I>, <I>ATP6V1B1</I> or <I>SIX1</I>
  • Audiovestibular findings in patients with enlargement of the vestibular aqueduct caused by mutations of SLC26A4, ATP6V1B1 or SIX1
公開日
2013
資源種別
journal article
DOI
  • 10.3757/jser.72.97
公開者
一般社団法人 日本めまい平衡医学会

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説明

Enlargement of the vestibular aqueduct (EVA) is the most common malformation of the inner ear. EVA can be observed in various disorders including DFNB4/Pendred syndrome, branchio-oto-renal/branchio-oto (BOR/BO) syndrome, and distal renal tubular acidosis (dRTA). Characteristic phenotypes of EVA include progressive, fluctuating hearing loss (HL), and repetitive vertigo. In this study, we compared the audiovestibular findings in patients with mutations of SLC26A4, ATP6V1B1 or SIX1 to clarify whether the anatomical enlargement itself was related to the characteristic phenotypes. We enrolled five Pendred syndrome patients with SLC26A4 mutations, one dRTA patient with ATP6V1B1 mutations and two BO syndrome patients with a SIX1 mutation. One patient with a SIX1 mutation showed unilateral EVA, and the others had bilateral EVA. All five patients with SLC26A4 mutations had progressive HL, fluctuating HL and/or repetitive vertigo. A patient with ATP6V1B1 mutations also showed repetitive progression HL, fluctuating HL and repetitive vertigo. Fluctuating HL and repetitive vertigo were not recognized in two patients with SIX1 mutation, although one patient showed slight progression of HL. There were no significant positive associations in patients with SLC26A4 mutations between EVA widths and pure tone averages, and the widths and maximum slow phase velocities. These findings suggested that EVA itself had no relationship with either progressive, fluctuating HL, nor repetitive vertigo. The product of SLC26A4, the Cl-/HCO3- exchanger pendrin, and the product of the ATP6V1B1, B1-subunit of H+-ATPase, can play a role in the maintainance of endolymph pH homeostasis. Therefore, a disruption of endolymph pH homeostasis can be associated with the characteristic phenotypes.

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