ASSOCIATION OF DENGUE VIRUS TYPE-SPECIFIC IGG ON PLATELETS IS SPECIFIC FOR THE ACUTE PHASE IN AN IMPORTED JAPANESE PATIENT WITH SECONDARY DENGUE 2 VIRUS INFECTION

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  • OISHI KAZUNORI
    Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University
  • INOUE SHINGO
    Department of Virology, Institute of Tropical Medicine, Nagasaki University
  • KURAMOTO TSUYOSHI
    Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University
  • ONIZUKA SHOZABURO
    Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University
  • SAITO MARIKO
    Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University
  • HASEBE FUTOSHI
    Department of Virology, Institute of Tropical Medicine, Nagasaki University
  • MORITA KOUICHI
    Department of Virology, Institute of Tropical Medicine, Nagasaki University
  • NAGATAKE TSUYOSHI
    Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University

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The mechanism of thrombocytopenia in dengue virus infection remains unknown. We report herein an imported case of a 21-year-old male Japanese with dengue fever caused by secondary dengue 2 virus infection. The thrombocytopenia detected around the day of defervescence was associated with an increased level of platelet-associated IgG (PAIgG). The eluate from the platelets during the acute phase of this case contained an increased activity of anti-dengue virus 2 IgG, while the eluate from platelets during the convalescent phase contained a low level of anti-dengue 2 IgG. These findings suggest the transient formation of PAIgG involving anti-dengue 2 virus IgG during the acute phase of secondary dengue 2 virus infection.

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