蛋白欠乏食飼養ラットにおけるニューモシスチス・カリニ肺炎の発症について

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  • Manifestation of Pneumocystis carinii pneumonia in rats with protein deficient malnutrition.
  • タンパク ケツボウ ショクシヨウ ラット ニ オケル ニューモシスチス カリニ

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The role of protein deficient malnutrition in Pneumocystis carinii pneumonia was examined on rats. Twenty-nine Wistar male rats were divided into 3 groups. Of 10 rats fed with protein-free diet (Group A) 7 manifested light to moderate P. carinii pneumonia, whereas none of 10 rats fed with low (8.2%) protein diet (Group B) showed P. carinii infection probably due to the excess uptake of the diet. On the other hand, all of 9 rats fed with normal protein (24.1%) diet with cortisone acetate treatment, 125 mg/kg twice weekly, acquired moderate to severe infections with P. carinii. From the results mentioned above, it is apparent that P. carinii infection could be provoked by the lack of protein in the diet.

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