Seasonal differences in antimalarial activity of hot-water extract of Dichroa febrifuga leaves against Plasmodium yoelii 17XL in ICR mice, with reference to febrifugine and isofebrifugine content.

DOI Web Site Web Site 被引用文献1件 参考文献14件
  • Ishih Akira
    Department of Parasitology, Hamamatsu University School of Medicine
  • Fujii Kaori
    Department of Parasitology, Hamamatsu University School of Medicine
  • Sakai Mikako
    Department of Parasitology, Hamamatsu University School of Medicine
  • Iiboshi Masami
    Department of Pharmacognosy, School of Pharmaceutical Sciences, University of Shizuoka
  • Miyase Toshio
    Department of Pharmacognosy, School of Pharmaceutical Sciences, University of Shizuoka
  • Terada Mamoru
    Department of Parasitology, Hamamatsu University School of Medicine

この論文をさがす

説明

The antimalarial activity of the hot-water extract of leaves and roots of Dichroa febrifuga was evaluated against Plasmodium yoelii 17XL in ICR mice. Untreated control mice died with a gradual body weight loss and increase of parasitemia by day 9 after infection. The hot-water extract of leaves collected in June showed an antimalarial activity, and furthermore the possible adverse side effect was also observed. All mice given orally the extract of leaves (0.1 g/ml) collected in June died by day 9 without parasite multiplication. The mice given the lower concentration (0.025 g/ml) of the same leaf extract showed low parasitemia levels during administration. Following a transient increase of malaria parasites in the bloodstream, no parasites could be detected by a microscopic examination, and all mice survived during the experiment. On the other hand, the extract of leaves (0.1 g/ml) collected in December showed no activity. The extract of roots (0.1 g/ml) of D. febrifuga collected in December, however, had an antimalarial activity, and three mice out of four survived during the experiment. The leaves collected in June contained about 30 times as much febrifugine and isofebrifugine mixture as those in December.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (14)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ