Pathological study of mouse brain infected with wild type strains of dengue virus type 2.

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  • デングウイルス２型野生株による感染マウス脳の病理組織学的変化
  • デング ウイルス 2ガタ ヤセイシュ ニ ヨル カンセン マウス ノウ ノ

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Abstract

Histological observations were carried out on the brains of mice inoculated intracerebrally (i.c.) with two wild type strains of dengue virus type 2. Mortalities of the infected mice were studied in parallel. The effects of serial passage in suckling mice were especially investigated.<BR>Although a few death occurred after i. c. inoculation of both parent wild type strains which had not been passed in suckling mouse brain, the mortalities increased as the passage levels. By the tenth passage, the mortalities reached 100 per cent.<BR>Both parent wild type strains produced no striking histological changes in the brains after i. c. inoculation. However by the fifth passage, diffused edema, extensive perivascular cuffs and abscess formation in the cortex of the brain were observed.

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