Fabrication of hollow fiber membrane of 6FDA polyimide and design of novel membrane oxygenator.

DOI 2 Citations 13 References
  • MORI Y.
    Department of Industrial Chemistry, Faculty of Engineering, Tokyo Metropolitan University
  • KAWAKAMI H.
    Department of Industrial Chemistry, Faculty of Engineering, Tokyo Metropolitan University
  • NAGAOKA S.
    Department of Industrial Chemistry, Faculty of Engineering, Tokyo Metropolitan University
  • KUBOTA S.
    Department of First Surgery, St. Marianna University School of Medicine
  • KANAMORI T.
    National Institute of Materials and Chemical Research

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Other Title
  • ６ＦＤＡポリイミド中空糸膜の作製と新しい膜型人工肺への応用

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Description

A novel asymmetric hollow fiber of 6FDA polyimide has been fabricated for intravascular oxygenator (IVOX) device. A dry/wet phase in-version process has been applied to a spinning process to prepare an asymmetric polyimide hollow fiber. The outer surface of the hollow fiber consisted of an ultrathin skin layer. O2 and CO2 transfer rates of the polyimide hollow fiber were much larger than those determined in presently available polydimethylsiloxane (PDMS) hollow fiber and the transfer rates were similar to those measured in silicone-layer-coated polypropylene (Si-PP) hollow fiber. The hemocompatibility of the polyimide hollow fiber without heparinization has been evaluated in vitro and in vivo. The amount of platelets on the polyimide hollow-fiber surface measured in vitro was less than that on PDMS hollow fiber and Si-PP hollow fiber. The formation of thrombus estimated in vivo was not found. This means that the asymmetric polyimide hollow fiber shows excellent hemocompatibility.

Journal

  • Jinko Zoki

    Jinko Zoki 27 (1), 278-282, 1998

    JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

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