UTILITY OF THE ALLERPORT<sup>®</sup> HRT IN THE DIAGNOSIS OF HEN'S EGG ALLERGY: A PEDIATRIC MULTICENTER CHALLENGE STUDY

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  • Sato Sakura
    Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital
  • Ito Komei
    Department of Allergy, Aichi Children's Health and Medical Center
  • Urisu Atsuo
    Department of Pediatrics, Fujita Health University The Second Teaching Hospital
  • Kando Naoto
    Department of Allergy, Aichi Children's Health and Medical Center
  • Nakagawa Tomoko
    Department of Allergy, Aichi Children's Health and Medical Center
  • Tsuge Ikuya
    Department of Pediatrics, Fujita Health University
  • Kondo Yasuto
    Department of Pediatrics, Fujita Health University The Second Teaching Hospital
  • Ito Setsuko
    Department of Food Science and Nutrition, Faculty of Human Life and Science, Doshisha Women's College of Liberal Arts
  • Ebisawa Motohiro
    Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital

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Other Title
  • 好塩基球ヒスタミン遊離試験「アラポート<sup>®</sup>HRT」の鶏卵アレルギー診断への有用性（多施設共同研究）
  • 好塩基球ヒスタミン遊離試験「アラポートHRT」の鶏卵アレルギー診断への有用性(多施設共同研究)
  • コウエンキキュウ ヒスタミン ユウリ シケン 「 アラポート HRT 」 ノ ケイラン アレルギー シンダン エ ノ ユウヨウセイ(タシセツ キョウドウ ケンキュウ)

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Abstract

Purpose  This study aimed to evaluate the utility of the Allerport® HRT in the diagnosis of hen's egg allergy.  Method  We enrolled 51 subjects who underwent the Allerport® HRT before an oral food challenge (OFC) consisting of heated egg. Blood samples were collected within three months prior to OFC to measure histamine release (HR) and specific IgE antibody titers. We examined whether the Allerport® HRT was useful as a means of diagnosing hen's egg allergy and predicting severity of induced symptoms.  Of 51 subjects, three whose OFC results were not valid**1** and 13 who were classified as “low responders” to the Allerport® HRT (%HR due to anti-IgE below 20%) were excluded. Of the remaining 35 subjects (average age: 4 years), 23 showed positive reactions to the OFC. Quantities of histamine released in spontaneous HR and egg white (EW)- and ovomucoid (OVM)-induced HR were significantly higher in patients with positive reactions. In our receiver operating characteristic analysis, the area under the curve for %HR against 6ng/ml of EW was 0.9601 and that against 3ng/ml of OVM was 0.9022. The cutoff value was 15.0% for EW and 3.7% for OVM. The sensitivity was 95.7% for EW and 91.3% for OVM, and the specificity was 83.3% for EW and 58.3% for OVM. %HR correlated well with the severity of induced symptoms in the OFC.  Conclusion  Allerport® HRT is useful for the diagnosis of hen's egg allergy, and may also aid in predicting the severity of induced symptoms.

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