Regulatory Elements Directing Gut Expression of the GATA 6 Gene during Mouse Early Development
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- Sun-Wada Ge-Hong
- Division of Biological Sciences, The Institute of Scientific and Industrial Research, Osaka University
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- Kamei Yoichi
- Division of Biological Sciences, The Institute of Scientific and Industrial Research, Osaka University
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- Wada Yoh
- Division of Biological Sciences, The Institute of Scientific and Industrial Research, Osaka University
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- Futai Masamitsu
- Division of Biological Sciences, The Institute of Scientific and Industrial Research, Osaka University
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説明
The GATA 6 transcription factor, as well as GATA 4 and GATA 5, is expressed in a variety of mammalian tissues including the precardiac mesoderm and endoderm, and gut-related organs. Genetic studies have also implicated GATA factors as important regulators of gut endoderm development. Previously, we identified the promoter and a cardiac-specific enhancer of mouse GATA6 [Sun-Wada et al. (2000) J. Biochem. 127, 703-709], however, little is known about the regulatory elements that govern GATA6 expression in the primitive gut. Here, we identified a distal enhancer of the GATA 6 gene directing expression in the gut by creating transgenic mice. A sequence of approximately 200 bp between -8.0 kb and -7.8 kb contains element (s) that enhance transcription in the gut during embryonic development, when linked to the hsp 68 promoter/lacZ fusion gene. Our results also show that GATA 6 expression is controlled by multiple regulatory regions including cardiac-specific and gut-specific enhancers.
収録刊行物
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- The Journal of Biochemistry
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The Journal of Biochemistry 135 (2), 165-169, 2004
社団法人 日本生化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679940629760
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- NII論文ID
- 130003534649
- 10016198011
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- NII書誌ID
- AA00694073
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- COI
- 1:CAS:528:DC%2BD2cXktV2hu78%3D
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- ISSN
- 17562651
- 0021924X
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- NDL書誌ID
- 6887496
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- PubMed
- 15047717
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可