Glutamatergic Chemical Transmission: Look! Here, There, and Anywhere
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- Moriyama Yoshinori
- Department of Biochemistry, Faculty of Pharmaceutical Sciences, Okayama University
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- Yamamoto Akitsugu
- Department of Bio-Science, Faculty of Bio-Science, Nagahama Institute of Bio-Science and Technology
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Abstract
Vesicular glutamate transporter (VGLUT) is responsible for the active transport of L-glutamate in synaptic vesicles and thus plays an essential role in the glutamatergic chemical transmission in the central nervous system. VGLUT comprises three isoforms, VGLUT 1, 2, and 3, and is a potential marker for the glutamatergic phenotype. Recent studies indicated that VGLUT is also expressed in non-neuronal cells, and localized with various organelles such as synaptic-like microvesicles in the pineal gland, and hormone-containing secretory granules in endocrine cells. L-Glutamate is stored in these organelles, secreted upon various forms of stimulation, and then acts as a paracrine-like modulator. Thus, VGLUTs highlight a novel framework of glutamatergic signaling and reveal its diverse modes of action.
Journal
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- The Journal of Biochemistry
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The Journal of Biochemistry 135 (2), 155-163, 2004
The Japanese Biochemical Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679940637696
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- NII Article ID
- 130003534648
- 10016197940
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- NII Book ID
- AA00694073
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- COI
- 1:CAS:528:DC%2BD2cXktV2hu74%3D
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- ISSN
- 17562651
- 0021924X
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- NDL BIB ID
- 6887476
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- PubMed
- 15047716
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed