Serum Complement and Complement Components in the Patients with Glomerulonephritides and/or SLE

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  • Kurata Kaname
    Department of Internal Medicine, Faculty of Medicine, Keio University

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  • 各種腎炎および全身性紅斑性狼瘡における血清補体および補体成分の変動
  • カクシュ ジンエン オヨビ ゼンシンセイコウ ハンセイ ロウソウ ニ オケル ケッセイホタイ オヨビ ホタイ セイブン ノ ヘンドウ

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Abstract

It is well known that immunological events are concerned with pathogenesis of both glomerulonephritides and SLE. The purpose of this paper is to approach to these immunological events by analysing serum complement and some of complement components in these patients. In a total of 89 patients with glomerulonephritides and/or SLE, serum complement (CH50), Cl, C4, β_1C-_1A were estimated according to the methods of Mayer, Nelson, and the single radial immunodiffusion method, respectively. Following results were obtained. 1) Following the onset of acute glomerulonephritis and in active SLE, CH50 was low. The highest statistical correlation between CH50 andβ_1C-_1A was noticed in the former, while that between CH50 and C4 was seen in the latter. 2) In chronic glomerulonephritis, CH50 was normal, with lowered C1, elevated C4 and normalβ_1C-_1A (slightly decreased in the end stadium). 3) In nephrotic syndrome, CH50 was normal or slightly elevated with lowered C1, elevated C4, and normalβ_1C-_1A. This component profile resembled that of chronic glomerulonephritis. Brisk transient decrease of CH50 was seen in one nephrotic patient during his clinical course, without accompanying clinical exacerbation. 4) Lowered levels of CH50 were seen, not only, in almost all cases with SLE, but also in some cases with inactive SLE. Correlation between the severity of albuminuria and CH50 level was not always seen in SLE.

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