Bronchial Asthma and Asthma-like Dyspnea Caused by Inhalation of Simple Chemicals

DOI Web Site

Bibliographic Information

Other Title
  • 単純化学物質吸入による喘息および喘息様呼吸困難
  • タンジュン カガク ブッシツ キュウニュウ ニ ヨル ゼンソク オヨビ ゼンソク ヨウ コキュウ コンナン

Search this article

Abstract

Usually allergic asthma is thought to be an anaphylactic type of reaction in the lungs but recently a different pattern of bronchopulmonary hypersensitivity has been described in which pulmonary infiltrations occur in association with precipitating antibodies and a positive Arthus type skin reaction. Besides the above well-known picture of bronchial asthma, we have previously reported a delayed type allergic reaction of the skin and the lungs in guinea pigs as well as in man occurring after injection or inhalation of extracts of Candida albicans. In this paper reports of bronchial asthma and asthma-like dyspnea caused by occupational exposure to simple chemicals have been reviewed and these reactions could be devided into 4 types according to the allergologic patterns observed. (1) immediate type, (2) delayed type, (3) non allergic, irritative type, and (4) undetermined type reactions to these substances. Results of allergologic investigations consisted of inhalation test, skin test, and determination of circulating antibodies in each group have been summarized. To clarify the mechanism of dyspnea, immediate and late respiratory reactions in guinea pigs were recorded by oscillation method after frequent inhalation of simple chemicals such as potassium bichromate, formalin and/or paraphenylene diamine. However, no evidence of specific immunologic reactions was found. Possible explanations for these results were discussed.

Journal

Details 詳細情報について

Report a problem

Back to top