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COMPETENCE OF B CELLS TO HELPER T CELLS IN POKEWEED MITOGEN INDUCED IMMUNOGLOBULIN PRODUCTION
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- Kondo Naomi
- Department of Pediatrics, Gifu University School of Medicine
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- Orii Tadao
- Department of Pediatrics, Gifu University School of Medicine
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- Uetake Hisao
- Toyama Institute of Health
Bibliographic Information
- Other Title
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- Pokeweed Mitogen誘導免疫グロブリン産生系におけるヒト同種T-B細胞間の適格性の存在とその解析
- Pokeweed Mitogen ユウドウ メンエキ グロブリン サンセイケイ
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Description
Pokeweed mitogen (PWM)-induced polyclonal immunoglobulin (Ig) production of B cells is highly reproducible and the response has been shown to be dependent on T cells. Using T and B cells obtained from healthy individuals and patients with immunodeficiency, we investigated whether or not human helper T cells are able to collaborate with B cells in PWM-induced polyclonal Ig production across allogeneic barriers. It has become clear in our results that the B cell competence is required for T cell help in human lymphocytes. In other words, our results suggest that T cell help in PWM-induced Ig secretion of B cells may be restricted by allogeneic barriers. They also imply that in order to investigate the T cell helper activities of a (hypo)-gammaglobulinemia patients, their T cells should be tested in co-cultures not only with B cells of the third-party individuals but also with B cells of family members of the patients.
Journal
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- Japanese Journal of Allergology
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Japanese Journal of Allergology 30 (6), 281-288, 1981
Japanese Society of Allergology
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Details 詳細情報について
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- CRID
- 1390282679946241024
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- NII Article ID
- 110002412152
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- NII Book ID
- AN00012583
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- ISSN
- 13477935
- 00214884
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- NDL BIB ID
- 2352719
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL Search
- CiNii Articles
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- Abstract License Flag
- Disallowed