COMPETENCE OF B CELLS TO HELPER T CELLS IN POKEWEED MITOGEN INDUCED IMMUNOGLOBULIN PRODUCTION

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  • Pokeweed Mitogen誘導免疫グロブリン産生系におけるヒト同種T-B細胞間の適格性の存在とその解析
  • Pokeweed Mitogen ユウドウ メンエキ グロブリン サンセイケイ

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Pokeweed mitogen (PWM)-induced polyclonal immunoglobulin (Ig) production of B cells is highly reproducible and the response has been shown to be dependent on T cells. Using T and B cells obtained from healthy individuals and patients with immunodeficiency, we investigated whether or not human helper T cells are able to collaborate with B cells in PWM-induced polyclonal Ig production across allogeneic barriers. It has become clear in our results that the B cell competence is required for T cell help in human lymphocytes. In other words, our results suggest that T cell help in PWM-induced Ig secretion of B cells may be restricted by allogeneic barriers. They also imply that in order to investigate the T cell helper activities of a (hypo)-gammaglobulinemia patients, their T cells should be tested in co-cultures not only with B cells of the third-party individuals but also with B cells of family members of the patients.

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