Macrophage Soluble Factors in Antibody Formation in Vitro

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  • Takata Masaru
    The Second Department of Internal Medicine, School of Medicine, Chiba University

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  • マクロファージ由来可溶性因子の抗体産生における役割
  • マクロファージ ユライ カヨウセイ インシ ノ コウタイ サンセイ ニ オケル

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Abstract

Helper function of macrophages on antibody formation of macrophage-depleted spleen cells in vitro was studied. To obtain maximal antibody response on day 4, optimal number of thioglycollate-stimulated macrophage was required, irrespective of dose of antigne in culture. This macrophage function was replaced by the dialyzed supernatants obtained from culture of thioglycollate-stimulated macrophages for 24 hr. Macrophages also could release antigen specific factor(s) which assist antibody formation in vitro as well as antigen nonspecific factor. Production of these factors was varied with the state of macrophage, thioglycollate stimulated or not, and the nature of antigen which had been added to the macrophage culture.

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