Commparative Study of Serum IgE in Various Respiratory Diseases and Changes of Serum IgE in Patients with Bronchial Asthma

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  • Yamaguchi Michiya
    The First Department of Internal Medicine, School of Medicine, Nihon University

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  • 血清 IgE 値の各種呼吸器疾患における比較と気管支喘息での変動について
  • ケッセイ IgEチ ノ カクシュ コキュウキ シッカン ニ オケル ヒカク ト

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The serum IgE levels in 787 cases of various respiratory diseases, 35 cases of non-respiratory diseases and 19 cases of normal controls were measured using indirect single radial immuno-diffusion method. The changes of serum IgE levels by the influence of the various treatments as specific and non-specific hyposensitization and symptomatic therapy were studied in the patients with bronchial asthma and nasal allergy. The following results were obtaind. 1. Serum IgE levels in normal individuals were below 340 unit/ml. 2. The serum IgE levels in the Patients with bronchial asthma, nasal allergy, pulmonary cyst and interstitial pneumonitis showed significant increase. High serum IgE levels in some patients with pulmonary sarcoidosis, bronchiectasis, pulmonary emphysema, pulmonary tuberculosis, lung cancer and chronic bronchitis were seen, however, there were no significant correlationship among these respiratory diseases and normal individuals. 3. Serum IgE concentrations were elevated in the groups of atopic type and mixed type of the patients with bronchial asthma. There were no differences in the serum IgE levels between the groups of idiopathic type and normal controls. Serum IgE levels were decreased markedly by long term specific hyposensitization of house dust (P<0.001). There were no changes of serum IgE levels by short term glucocorticoid therapy, however, serum IgE levels were decreased by long term glucocorticoid therapy (P<0.02). Serum IgE levels were decreased by the gold therapy as the aurothioglucose (P<0.02). There were no changes by the treatments of disodium cromoglycate, normal human γ-globulin combined histmaine and the bronchodilators.

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