Correlation between T- and B-Lymphocytes Pools and their Functions in the Patients with Systemic Lupus Erythematosus

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  • Arimori Shigeru
    The Second Department of Internal Medicine, Medical School, Okayama University
  • Kobashi Hidehiro
    The Second Department of Internal Medicine, Medical School, Okayama University
  • Tada Shinya
    The Second Department of Internal Medicine, Medical School, Okayama University
  • Nakata Yasunari
    The Second Department of Internal Medicine, Medical School, Okayama University
  • Koriyama Kenji
    The Second Department of Internal Medicine, Medical School, Okayama University
  • Ichikawa Yukinobu
    The Second Department of Internal Medicine, Medical School, Okayama University

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Other Title
  • 全身性エリテマトーデス患者の T, B 細胞のプールと機能の相関
  • ゼンシンセイ エリテマトーデス カンジャ ノ T Bサイボウ ノ プール ト

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The T- and B-lymphocyte pools, PHA-P and PWM reactive lymphocytes obtained from the patients with systemic lupus erythematosus were examined simultaneously. The sheep red blood cell rosette-forming cell is used as T-lymphocytes marker, and suface immunoglobulin bearing cell as B-lymphocytes marker. The lymphocyte cultures were performed using PHA-P and PWM as mitogens in combination with 3H-TdR incorporation rate. Remarkable variations of obtained data were noticed in comparing to the data of normal subjects. The correlation between T-lymphocytes and PHA-P reactive lymphocytes consisted in two groups within statistically significant range (P<0.05). The correlation between B-lymphocytes and PWM reactive lymphocytes exsisted negatively in the 8 patients out of 12 patients examined of systemic lupus erythematosus. The surface receptors of T- and, especially, B-lymphocytes are seemed to be modified with antibody, following the induction of lymphocytes abnormality in cell number and in function too, been concerning with the pathogenesis of the systemic lupus erythematosus.

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