STUDIES ON EXPERIMENTAL ASTHMA : II. Transient Airway Narrowing in Guinea Pigs Passively Sensitized with Homocytotropic Antibodies

DOI Web Site
  • Suzuki Shuji
    Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo
  • Igarashi Hiroshi
    Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo
  • Koizumi Kazuhiro
    Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo
  • Muranaka Masaharu
    Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo

Bibliographic Information

Other Title
  • 実験喘息の基礎的研究 : II. 同種抗体で感作されたモルモットにおける一過性気道狭窄
  • 実験喘息の基礎的研究-2-同種抗体で感作されたモルモットにおける一過性気道狭窄
  • ジッケン ゼンソク ノ キソテキ ケンキュウ 2 ドウシュ コウタイ デ カン

Search this article

Abstract

The changeability of airway narrowing is one of the main feature of human asthma. There have veen, however, no suitable means to directly demonstrate, assess or analyze such a phenomenon in experimental animals. In the present study, guinea pigs were passively sensitized with homocytotropic antibodies to yueld reproducible anaphylactic responses. Guinea pigs injected intravenously with anti-egg albumin antiserum were challenged intravenously with 500 μg of the antigen at 1, 4, 8 or 21 days after sensitixation. Their symptoms were graded according to the arbitrary system proposed by Ambrus. Tracheal sensitivity was assessed in vitro by the minimal concentration of antigen necessary to give a positive anaphylactic reaction. The time course of tracheal anaphylactic response was observed in vitro. The in vitro reactions appear to be representative of at least two aspects of the in vivo occurrences. First, there was a significant correlation between the rating of the in vivo response and the grade of tracheal sensitivity assessed in vitro (p<0.01). Secondly, the spontaneous relaxation demonstrated in vitro corresponded well to the trasient dyspnea observed in vivo. Neither the addition of anti-adrenergic agents or anti-purinergic one into bathing solutions nor the deletion of an anti-cholinergic agent from the solutions changed the half time of the tracheal anaphylactic contraction. Only an increased supply of oxygen lengthened the half time.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top