A Study on Clinical Features of Bronchial Asthma in School Children in Fuji City, Shizuoka Prefecture

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  • 富士市学童気管支喘息の臨床像に関する研究
  • フジシ ガクドウ キカンシ ゼンソク ノ リンショウゾウ ニカンスルケンキュウ

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Abstract

This study was performed to analyse clinical features of 163 school children diagnosed clinically as bronchial asthma in Fuji City, Shizuoka Prefecture in relation to air pollution of the district. The examination was performed during the years of 1968 to 1970, and the results were compared with those of inhabitants in adjacent areas with different degrees of pollution. The results are summarized as follows: 1. Male patients outnumbered females (in 3 areas). 2. The incidence of previous history of allergic manifestations and/or a history of familial susceptibility was more frequent in the affected children than in non-asthmatic children in the same area. 3. The onset of the asthma was mostly in the age yonger than 5 years, being inclined slightly to lower ages in the highly polluted area. 4. There exists conspicuous increase in the frequency of attacks in particular seasons, i.e. fall for general popullations and winter for the markedly polluted area. 5. The increase of eosinophiles was observed in peripheral blood, nasal discharge and sputum of the patients. 6. Bronchial hypersensitive responses to 2.5% methacholine aerosols were demonstrated in the patients living in all polluted areas. 7. The persentage of patients with the positive skin reaction to commercial house dust allergens was lower than that of the outpatients in our clinic at Chiba University, while the incidence of the positive skin reaction to the allergens prepared from their own house dust and to pine pollen and some kinds of fungi was found to be increased. 8. In the patients of the highly polluted area IgG level in the serum was generallylow. An elevation of IgE concentration was also demonstrated in an approximately half of the patients. These results indicate that the bronchial asthma observed among the children in polluted areas presents the same clinical features and laboratory findings as those usually observed at outpatient clinics. Namely, the patients may have the allergic predisposition and the manifestations may be induced on the basis of allergic reaction.

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