Cell-Mediated Immunity to Possible Tissue Antigens in Autoimmune Diserses as Evaluated by Leukocyte Migration Test : III. Acquired Immune Hemolytic Disorders

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  • Okimoto Yoshiharu
    The Second Medical Clinic, Department of Medicine, School of Medicine, Kyoto University

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Other Title
  • 自己免疫性疾患における白血球遊走阻止試験に関する研究 : 第3編 自己免疫性溶血症における赤血球膜に対する白血球遊走阻止試験
  • 自己免疫性疾患における白血球遊走阻止試験に関する研究-3-自己免疫性溶血症における赤血球膜に対する白血球遊走阻止試験
  • ジコ メンエキセイ シッカン ニ オケル ハッケッキュウユウソウ ソシ シケン ニ カンスル ケンキュウ 3 ジコ メンエキセイ ヨウケツショウ ニ オケル セッケッキュウ マク ニ タイスル ハッケッキュウユウソウ ソシ シケン

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Abstract

Cell-mediated immunity to human red cell membrane of O-type was investigated by Sφborg's leukocyte migration test, in six patients with idiopathic acquired immune hemolytic disease, one SLE patient associated with symptomatic acquired immune hemolytic disease, one patient with hepato-thyroiditis syndrome (Fukase, Ito) associated with Coombs' test-negative hemolysis, one patient with Hodgkin's disease associated with Coombs' test-negative hemolysis, and one patient with paroxysmal nocturnal hemoglobinuria. 1) LMT with red cell membrane was positive in one and weakly positive in three out of seven patients with Coombs' test-positive acquired immune hemolytic disease. One patient who had shown weakly positive LMT, became nagative with the LMT under the immunosuppressive treatment. 2) One patient with hepato-thyroiditis syndrome associated with Coombs' test-negative hemolysis showed weakly positive LMT with red cell membrane. However, the LMT in a patient with Hodgkin's disease associated with Coombs' test-negative hemolysis was negative. A patient with paroxysmal nocturnal hemoglobinuria showed negative LMT with the same antigen. It was suggested that CMI as well as humoral immunity to red cell membrane would be an important pathogenetic factor in some idiopathic and symptomatic acquired immune hemolytic diseases.

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