CLINICAL STUDIES OF BRONCHIAL ASTHMA INDUCED BY CHIRONOMID MIDGES

DOI 10 Citations
  • Murakami Gyokei
    Department of Pediatrics, Toyama Medical and Pharmaceutical University
  • Igarashi Takao
    Department of Pediatrics, Toyama Medical and Pharmaceutical University
  • Saeki Yoko
    Department of Pediatrics, Toyama Medical and Pharmaceutical University
  • Adachi Yuichi
    Department of Pediatrics, Toyama Medical and Pharmaceutical University
  • Matsuno Masatomo
    Department of Pediatrics, Toyama Medical and Pharmaceutical University
  • Okada Toshio
    Department of Pediatrics, Toyama Medical and Pharmaceutical University
  • Kawai Koichi
    Department of Bacteriology and Immunology, Toyama Medical and Pharmaceutical University
  • Kumagai Akira
    Vice-President, Toyama Medical and Pharmaceutical University
  • Sasa Manabu
    President, Toyama Medical and Pharmaceutical University

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  • ユスリカ喘息に関する研究

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A total of 150 asthmatic children were investigated by prick test for the presence of allergenicities against chironomid antigens. The percentage of cases who showed positive prick tests to the antigens of Polypedilum kyotoense, Chironomus yoshimatsui, Tokunagayusurika akamusi(adlt & larvae)and Dermatophagoides farinae were 22.0%, 16.7%, 8.0%, 14.7%, 94.0%, respectively. In addition, Phadezyme RAST were made with the previously tested 3 midge antigens on a total of 51 asthmatic cases. There were positive-correlations between the results of RAST and those of prick tests. The correlation between the wheal size in the prick test, the threshold dilution in the intradermal test, the RAST score, and the result of the provocation test were examined in 16 asthmatics. In 9 asthmatic children with the positive prick test, the threshold dilutions were all less than 10^<-4>, RAST scores were 2 or above in 6, and the provocation tests were positive in 7. This clearly show that strong positive-correlations exist. The cross reactivity between Dermatophagoides farinae and Polypedilum kyotoense was investigated by RAST inhibition tests. The antigens causing allergic reactions were quite independent of each other. In conclusion, extracts of chironomid midges have strong allergenicities, and constitute one of the more important inhalant antigens together with Dermatophagoides farinae.

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