A CASE OF FOOD-DEPENDENT-EXERCISE INDUCED ANAPHYLAXIS POSSIBLY INDUCED BY SHLLFISH (SULCULUS SUPERTEXTA AND TURBO CORNUTUS)

DOI 5 Citations
  • Juji Fumiko
    Department of Pediatrics, Faculty of Medicine, University of Tokyo
  • Takashima Hiroya
    Japan Asthma and Allergy Clinic
  • Suko Matsunobu
    Department of Internal Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo
  • Doi Makoto
    Department of Internal Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo
  • Takaishi Toshiaki
    Department of Internal Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo
  • Okudaira Hirokazu
    Department of Internal Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo
  • Ito Koji
    Department of Internal Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo
  • Miyamoto Terumasa
    Department of Internal Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo

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Other Title
  • 巻貝が関与した食餌依存性運動誘発アナフィラキシー(Food-Dependent Exercise Induced Anaphylaxis)と思われる一症例

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A 17 years old girl experienced an anaphylactic reaction of urticaria, dyspnea, syncope and hypotension while riding a bicycle 55 minutes after eating shellfish Lapas shellfish which was a-like Sulculus Supertexta (SS). She recovered within several hours after the emergency treatment. Another attack occurred 3 months later while she was running with a dog 30 minutes after eating shellfish (Turbo Cornutus; TC). RAST scores were 4 for Lapas and 2 for TC. RAST inhibition test by ERISA showed a high crose-reaction between keyhole limpet hemocyanin (KLH) and Lapas, and between KLH and TC, while the cross reaction between Lapas and TC was low. Gel chromatography with sephacryl G-200 revealed that both Lapas and TC had several allergens with different molecules which were detected by ELISA. Exercise challenge produced an immediate fall of FEV_1 and a significant increase in plasma histamine levels for 45 minutes.

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