INVOLVEMENT OF ALLERGIC MECHANISM IN MINIMAL CHANGE NEPHROTIC SYNDROME (MCNS)

DOI
  • Boku Shousuke
    The Department of Nephrology, Showa University School of Medicine
  • Shinbo Hidemitsu
    The Department of Nephrology, Showa University School of Medicine
  • Akagi Taro
    The Department of Nephrology, Showa University School of Medicine
  • Totsuka Daisuke
    The Department of Nephrology, Showa University School of Medicine
  • Shibata Takanori
    The Department of Nephrology, Showa University School of Medicine
  • Saito Kenichi
    The Department of Nephrology, Showa University School of Medicine
  • Kitazawa Kouzo
    The Department of Nephrology, Showa University School of Medicine
  • Ito Shogo
    The Department of Nephrology, Showa University School of Medicine
  • Sugisaki Tetsuzo
    The Department of Nephrology, Showa University School of Medicine

Bibliographic Information

Other Title
  • 成人発症リポイドネフローゼにおけるアレルギー因子の関与の検討 : 特にダニ抗原の関与について

Search this article

Abstract

In this study we evaluated the involvement of allergic mechanisms in patients with adult onset MCNS (17 cases) by measuring serum IgE levels and RAST scores to house dust 1 (H.D.1), house dust 2 (H.D.2), Dematophagoides farinae (D.f.), Dermatophagoides ptenonyssinus (D.p.). Out of the 17 cases, three cases showed high levels of IgE (more than 1000 IU/ml) and the mean level of serum IgE was 877 IU/ml before treatment. All cases were treated with steroid and/or cyclophosphamide. After the treatment, all cases returned to remission. The level of IgE decreased to the normal range in four out of seven cases which had shown high levels of IgE before treatment. RAST was carried out on seven of the 17 cases. RAST scores for D.f. and D.f. were found to be positive in three cases, but these became negative in two cases after treatment. In five cases relapsed, the all cases showed to have the increased level of serum IgE and two of four cases which were examined RAST score showed to have the increased RAST score for D.f. and D.p. Thus, the data indicated that allergic mechanism, especially against D.f. and D.p. antigen, seemed to play one of the factors in the pathogenesis of MCNS.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top