EOSINOPHIL COLONY STIMULATING FACTOR (Eo-CSF) ACTIVITY AND SOLUBLE INTERLEUKIN-2 RECEPTOR (sIL-2R) IN PATIENTS WITH REACTIVE EOSINOPHILIA

DOI 1 Citations 11 References
  • Watanabe Kanji
    Third Department of Internal Medicine, Dokkyo University School of Medicine
  • Enokihara Hideo
    Third Department of Internal Medicine, Dokkyo University School of Medicine
  • Saito Kenji
    Third Department of Internal Medicine, Dokkyo University School of Medicine
  • Furusawa Shinpei
    Third Department of Internal Medicine, Dokkyo University School of Medicine

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  • 反応性好酸球増多症患者におけるリンパ球由来好酸球コロニー刺激因子 (Eo-CSF) 活性と血清中可溶性 Interleukin-2受容体 (sIL-2R) について

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To explore the pathophysiology of patients with reactive eosinophilia from unknown cause, we measured the eosinophil colony stimulating factor (Eo-CSF) activity in the interleukin-2 (IL-2) stimulated lymphocyte conditioned medium (CM) prepared from 22 patients with reactive eosinophilia. Eo-CSF activity, the levels of interleukin-5 (IL-5) and granulocyte-macrophage colony stimulating factor (GM-CSF) were increased in the CM from patients with high IgE levels. Hyrdrocortisone decreased the level of Elo-CSF in the CM. Elevated Serum levels of soluble IL-2 receptor (SIL-2R) were presented in 1:3 out of 15 patients with eosinophilia. The sIL-2R levels in patients with marked eosinophilia (>3000/μl) were higher than those in patients with mild eosinophilia ((≦3000/μl). High sIL-2R levels were noted in T cell CM from 3 out of 15 patients and in eosinophil CM from 1 out of 4 patients. These data suggested that lymphocyte from eosinophilic patients with elevated IgE produce Eo-CSF, IL-5 and GM-CSF by IL-2 stimtuation. Eo-CSF production is inhibited by hydrocortisone. SIL-2R is released from lymphocyte and in some case may be released from eosinophils.

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